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KMID : 0369819970270030173
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 3 p.173 ~ p.179
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Effect of a Water Soluble Dimethyl Dimethowy Biphenylate Derivative on the Carbon Tetrachloride Induced Hepatotoxicity in Rats
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문전옥/Moon JO
정경욱/김수현/김남득/이성광/양희선/이치호/Cheung KO/Kim SH/Kim ND/Lee SK/Yang HS/Lee CH
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Abstract
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A water-soluble DDB derivative (Bis{2-(methylamino)ethyl}-4,4-dimethoxy-5,5',6,6'-dimethylenedioxy-biphenyl-2,2'-dicarboxylate, DDB-S) was synthesized and its therapeutic effects on the liver damage induced by carbon tetrachloride in rats were evaluated. Oral administration of DDB-S reduced the aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activities and increased total protein and albumin contents in the serum of the carbon tetrachloride intoxicated rat. Therapeutic effects of DDB-S by intravenous injection was also investigated using carbon tetrachloride intoxicated rats. Histological studies showed that IV injection of DDB-S had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication and also prevented the elevation of liver weigh/body weight ratio. IV administration of DDB-S to CCl4?treated rats significantly decreased AST & ALT activities and also prevented the decrease of aniline hydroxylation activity of the liver. These results indicate that i.v. administration of DDB-S is very effective in recovering the liver function in CCl4?treated rats.
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KEYWORD
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Water soluble DDB derivative, Hepatoprotective effect
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